Benefits of Metformin on Fertility
How Metformin Works
Metformin has many actions, the main being suppression of endogenous glucose production by the liver. Metformin helps improve fertility. Metformin does not cause hypoglycemia, weight gain, unfavorable alteration of lipids, nor increase insulin secretion.
Unlike drugs such as Avandia, Metformin does not cause weight gain, fluid retention, or potential idiosyncratic hepatotoxicity. Instead, Metformin improves the effectiveness of insulin while maintaining or even decreasing insulin levels.
Helps to Induce Ovulation
According to research published by The Journal of Clinical Endocrinology and Metabolism, metformin can help to improve ovulation for women, especially those suffering from PCOS, by improving their insulin sensitivity, reducing gluconeogenesis, and reducing overall androgen production. In fact, studies also found that when compared to a placebo, metformin had a direct impact on inducing ovulation for infertile women dealing with PCOS. This is primarily because women’s menstrual cycles become more regulated while on metformin, thus helping to induce ovulation in users.
Reduces Risks of Ovarian Hyperstimulation Syndrome (OHSS)
Ovarian Hyperstimulation Syndrome, otherwise known as OHSS, is another risk oftentimes correlated with infertility and infertility treatments such as ICSI or IVF. When patients are administered infertility drugs, they are put at a heightened risk of developing OHSS, especially women who have PCOS. However, according to the National Library of Medicine, metformin may be beneficial in combating OHSS by helping to reduce users' typical increase in their body weight as well as circulating progesterone and estradiol and vascular permeability. In turn, patients can still receive their IVF or ICSI treatments and have a much lower risk of developing OHSS.
As mentioned previously, many women who deal with PCOS tend to put weight on much quicker and easier and are more prone to obesity or other weight-related health issues. Metformin, however, has been studied and suggested to help reduce weight in women, especially those suffering from Obese PCOS as mentioned above. As their weight levels decrease, their bodies are more able to properly ovulate, thus helping to increase their chances of a successful pregnancy.