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A Recent Metformin Study in People with Diabetes

May 31

Several studies have indicated that it can help people live prolonged, joyful, and healthier lives if used properly. Numerous studies in diabetes demonstrate a lower risk of several age-related disorders, such as diabetes, dementia, cognitive impairment, and pancreatic cancer. According to a growing body of data, Metformin is more than just a diabetes medication.

Older people are more likely to develop cancer than younger people. More than a few studies have found that taking Metformin reduces one's risk of developing colon or pancreatic cancer. In a UK retrospective analysis, 62,809 people with diabetes over 40 who had started diabetes therapy were assessed for their outcomes. Sulfonylurea and Metformin, both (combination treatment), and insulin were given to four different subgroups of the participants in the study. Researchers discovered that those who used Metformin were less likely to get the disease in the colon and pancreatic cancer.

Through a series of experiments on cancer cell lines and specifically bred mice, the scientists examined Metformin’s impact on a specific subset of tumor-attacking immune cells (called CD8TILs) and uncovered the following:

  • Metformin activates the generation of reactive oxygen species (ROS) in the mitochondria of CD8TILs
  • These ROS activate growth pathways in CD8TILs, thus increasing their proliferation
    (Translation: Metformin helps make more cancer-killing cells)
  • Metformin alters the tumor microenvironment to favor death of tumor cells by causing CD8TIL to robustly secrete interferon-ɣ
    (Translation: Metformin helps cancer-killing cells make more anti-cancer goodness)

As we grow older, we become more susceptible to chronic diseases such as cancer and diabetes and neurological and cardiovascular diseases. According to the available evidence, Metformin's anti-aging properties should reduce the probability of getting one of these age-related illnesses in the future.